//revistas.unisanitas.edu.co/index.php/rms <p>La Revista Médica Sanitas es una publicación trimestral de la Fundación Universitaria Sanitas, que tiene como propósitos divulgar las investigaciones científicas generadas por los miembros de la Universidad y por la comunidad médica iberoamericana, y generar debates de actualidad en temas médicos. En este sentido, la Revista Médica Sanitas aporta a los procesos de formación académica en medicina y a la actualización de los profesionalesde la salud.</p> <p>DOI: <a id="m_8040553861476042989LPlnk622715" href="https://doi.org/10.26852/issn.0123-4250" target="_blank" rel="noopener" data-saferedirecturl="https://www.google.com/url?q=https://doi.org/10.26852/issn.0123-4250&amp;source=gmail&amp;ust=1615561569285000&amp;usg=AFQjCNGP_9XZxmrk47XBNmCZ5mOQsBA5Hg">https://doi.org/10.26852/issn.<wbr />0123-4250</a></p> Fundación Universitaria Sanitas es-ES Revista Médica Sanitas 0123-4250 //revistas.unisanitas.edu.co/index.php/rms/article/view/744 <p class="p1">Yellow fever (YF) has been a significant public health concern since its first description in the 15th centu-ry, affecting various critical periods throughout human history. It has caused incalculable suffering and indescribable misery among populations in the Americas, Europe (1). The management of multiple organ dysfunction, particularly acute liver failure secondary to YF in intensive care units (ICUs), requires a comprehensive, multidisciplinary, and aggressive approach aimed at stabilizing the patient, treating systemic complications, and, if necessary, preparing for liver transplantation (2). This protocol establishes the guidelines for the comprehensive management of adult patients with severe YF admit-ted to the ICU at Clínica Colsanitas. It includes clinical and paraclinical criteria for admission, addressing parameters of hepatic, renal, respiratory, cardiovascular, and neurological dysfunction. The therapeutic strategy encompasses continuous monitoring, personalized hemodynamic support, protective mechan-ical ventilation, renal replacement therapy, coagulopathy management guided by thromboelastography, and the use of intensive plasma exchange in selected cases. Additionally, metabolic, neurological, and nutritional support interventions are considered, as well as the evaluation for liver transplantation in exceptional situations.</p> José A Rojas G Carlos Álvarez-Moreno Fabio C. Romo E. Carolina Mendoza C. Kevin J. Cubides P. John J. Vallejo R. Natalia Pérez M. Francy E. Duarte Euler A. Alpala Juan M. Cardona G. Carlos Ortega Molina V. Rodrigo Merlano Álvarez Juan D. Palomar José Rojas Reyes Copyright (c) 2025 Revista Médica Sanitas 2025-04-25 2025-04-25 28 1 1 22 10.26852/01234250.744