Keywords
Farmacorresistencia microbiana
Control de infecciones
Regulación y control de instalaciones
Infección hospitalaria Anti-bacterial agents
Drug resistance
Bacterial
Infection control
Facility regulation and control
Cross infection
How to Cite
Abstract
Objective: To evaluate the impact of implementing an antibiotic management program on the incidence of Healthcare-Associated Infections (HAIs), bacterial resistance, and use of antibiotics expressed as defined daily doses per 1000 days/patient (DDD/1000 days/patient), at a University Hospital. Methodology: Information on the microbiological profile of the institution and the HAIs indexes was collected for 10 months. Simultaneously, a management process was implemented led by the infectious disease specialist. The prescription strategy comprised completing a form and the supervision of certain antibiotics by
the department of infectious diseases. The program was implemented for two months, with emphasis on education. After this intervention, the DDD/1000 days/patient data was collected, together with the antimicrobial resistance profile and the Institutions HAIs index. Results: A reduction in the use of antibiotics was observed in the second period for vancomycin, third generation cephalosporines, aminoglycosides, and carbapenems (56.8%, 52.3%, 49.2%, 47.9% and 44.5%, respectively). The reduction in costs in the use of antimicrobial agents was 19%. A significant reduction (p <0.01) in the number of methicillin resistant Staphylococcus aureus isolates and vancomycin resistant Enterococcus was achieved. The HAIs index dropped from 1 case per 1000 days of hospital stay, to 0.7 cases per 1000 days of hospital stay. Conclusion: The implementation of an antibiotic management program enables the mitigation of bacterial resistance, improves the HAIs indexes, and results in savings for the institution.
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