Keywords
Densidad ósea
Obesidad Leptin
Bone density
Obesity
How to Cite
Abstract
Purpose: To establish if there is a relationship between leptin levels and bone mineral density in obese patients belonging to an obesity program of an endocrinology service at a University Hospital. Methodology: A cross-sectional study was carried out between June of 2012 and June of 2014, in patients among 18-75 years old with body mass index ≥30 kg/m2. Anthropometric and paraclinical parameters were assessed (leptin levels and bone densitometry). A descriptive analysis of the information was performed and correlation between variables was estimated through the Pearson correlation coefficient. The statistical analysis was performed in STATA version 12. Results: 90 patients were included with an average age of 48 years old, mean leptin levels of 45 ng/ml and body mass index 36.8 Kg/m2. The coefficients of Pearson correlation between leptin and bone mineral density were for lumbar column -0.03, femoral neck -0.18 and total hip -0.25. An Anova test was applied for degree of obesity and bone mineral density in lumbar column, femoral neck and total hip, being significant for the last two, (p = 0.01) and (p = 0.0009). Multiple linear regression model found statistically significant associations between bone density total hip and leptin (coefficient of -0.002, (p = 0.017); it was not found associations between bone density of lumbar column and femoral neck with the levels of leptin. Conclusion: Our study found a weak relationship between leptin levels in obese patients and its effect on the mineral bone density ore in total hip adjusted by degree of obesity.
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