Abstract
To determine morbi-mortality and assess gestational age as a risk factor associated to mortality in preterm newborns. Methodology: ambispective cohort study from 2001 to 2006. Population: newborns whose gestational age is lower to 37 weeks, born alive between the first of January 2001 and the 31st of December 2006 in a third level health institution in Bogota, Colombia, whose target population is insured people associated to a private insurance company. Newborns whose gestational age was lower to 25 weeks were excluded. Sample size was 476 subjects with an expected mortality for newborns lower to 32 weeks of 8% and 2% for newborns whose gestational age was 32 weeks or more. Significance level was 0.05 and power of 80% with a relation 1:1. Sequential sampling was performed. Assessed variables included were birth year, gestational age, weight at time of birth, multiple gestations, gender, apgar, delivery way, maternal pathologies, diagnosis, interventions and complications. Analysis: early and late mortality were assessed through a uni and multivariate analysis. Results: 9273 births were obtained, 550 preterm (5.9%), male (54%). 69.45% between 33 and 36 weeks. Hypertensive maternal disease was the major cause of preterm delivery (p: 0.44). Major cause of hospital admissions were respiratory problems. Infection was the most frequent complication (33.2%) and main cause of mortality (37%). A total of 46 deaths was counted for which a neonatal mortality of 8.3x1000 was calculated. Early mortality was calculated in 63%. Conclusions: our mortality rate is similar compared to developed countries. Health policies must be improved to diminish the rate of infections, main cause of complications and mortality in our patients.
References
Mac Dorman M., Mathews T.J. Recent Trends in Infant Mortality in USA. National Center for Health and Human Services. 2008 Oct; 2008 (9). https://doi.org/10.1037/e565122009-001
Fondo de las Naciones Unidas para la Infancia. Salud Materna y Neonatal. En: Estado Mundial de la Infancia 2009 UNICEF. Serie de informes:p.10-118. Disponible en: www.unicef.org/spanish/sowc09/ docs/SOWC09-FullReport-ESP.pdf
Mamun A.A., Padmadass S.S., Khatun M. Maternal health during pregnancy and perinatal mortality in Bangladesh: evidence from a large-scale community-based clinical trial. Pediatr Perinat Epidemiol. 2006; 20(6):482-90. https://doi.org/10.1111/j.1365-3016.2006.00752.x
Chalmers B, Wen SW. Perinatal Care in Canada. BMC Women Health 2004; 4 Suppl 1:S 28. https://doi.org/10.1186/1472-6874-4-S1-S28
Kramer MS, Demissie K, Yang H, Platt RW. The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System. JAMA 2000 Aug; 284(7):843-9. https://doi.org/10.1001/jama.284.7.843
Departamento Nacional de Estadística. Recién Nacidos menores a 37 semanas. En: Estadísticas Vitales. Colombia: DANE; 2003.
Ministerio de Salud. Carga de la enfermedad en Colombia 1994.
Iams J.D., Romero R., Culhane J.F., Goldenberg R.L. Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth. Lancet 2008 Jan; 371(9607):164-75. https://doi.org/10.1016/S0140-6736(08)60108-7
Marret S., Ancel P.Y., Marpeau L., et al. Neonatal and 5-year outcomes after birth at 30-34 weeks of gestation. Obstet Gynecol 2007 Jul; 110(1):72-80.11. Lindner U, Hilgendorff A, Frey G, Gortner L. Drug Utilisation in Very Preterm Infants: Any Changes during the Past Decade? Klin Padiatr 2008 Jul-Aug ; 220(4): 238-42.
Dagle J.M., Lepp N.T., Cooper M.E., et al. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. Pediatr 2009 Apr; 123(4): 1116-23.
https://doi.org/10.1542/peds.2008-0313
Synnes A.R., Macnab Y.C., Oiu Z.,et al. Neonatal intensive unit characteristics affect the incidence of severe intraventricular hemorrhage. Med Care 2006;44(8):754-9
https://doi.org/10.1097/01.mlr.0000218780.16064.df
Teksam O., Kale G. The effects of surfactant and antenatal corticosteroid treatment on the pulmonary pathology of preterm infants with respiratory distress syndrome. Pathol Res Pract 2009; 205(1):35-41. https://doi.org/10.1016/j.prp.2008.08.004
Rogowski J.A., Horbar J.D., Staiger D.O., et al. Indirect vs. Direct Hospital Quality Indicators for Very-LowBirth-Weight Infants. JAMA 2004; 291(2):202-209. https://doi.org/10.1001/jama.291.2.202
Kusuda S., Fujimura M., Sakuma I., et al. Morbidity and mortality of infants with very low birth weight in Japan: center variation. Pediatr 2006 Oct;118 (4):1130-8
https://doi.org/10.1542/peds.2005-2724
Lopushanskii V.G., Kravchenko E.N. The perinatal mortality in the Omskaya Oblast Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2008 Mar-Apr; (2):15-8.
World Health Organization. Neonatal and Perinatal Mortality. Country, Regional and Global Estimates. Ginebra: OMS 2006;1-75.
Organización Panamericana de la Salud. La salud neonatal en el contexto de salud de la madre, el recién nacido y el niño para cumplir los objetivos de desarrollo del milenio de las Naciones Unidas. 47o Consejo Directivo, 58va. Sesión del Comité Regional. Washington, D.C. EUA: OPS. 2006 Sep 25-29
Hummler H.D., Poets C., Vochem M., et al. Mortality and morbidity of very premature infants in Baden-Wurttemberg depending on hospital size. Is the current degree of regionalization adequate? Z Geburts Neonat 2006 Feb;210(1):6-11. https://doi.org/10.1055/s-2006-931508
Itabashi K., Horiuchi T., Kusuda S., Kabe K., et al. Mortality rates for extremely low birth weight infants born in Japan in 2005. Pediatr 2009 Feb; 123(2):445-50.
https://doi.org/10.1542/peds.2008-0763
Markestad T., Kaaresen P.I., Ronnestad A., et al. Early death, morbidity and need of treatment among extremely premature infants. Pediatr 2005 May; 115(5):1289-98. https://doi.org/10.1542/peds.2004-1482
Ahmed S.H., Sarkis N.N., Fikry S.I. A study of neonatal morbidity and mortality at Damanhour Teaching Hospital Newborn Unit.J Egypt Public Health Assoc 2004;79 (5-6):399-414. Disponible en: http://www.ncbi.nlm.nih.gov/17265608
Grzona ME. Prematuros extremos. ¿Es posible establecer un límite de viabilidad? Acta Bioeth 2006; 12(1). https://doi.org/10.4067/S1726-569X2006000100014
Nwaesei C.G., Young D.C., Byrne J.M., Vincer M.J., Sampson D., Evans J.R., et al. Preterm birth at 23 to 26 weeks'gestation: is active obstetric management justified? Am J Obstet Gynecol 1987 Oct; 157(4 Pt1): 890-7. https://doi.org/10.1016/S0002-9378(87)80080-7
Evans N., Hutchinson J., Simpson J.M., et al. Prenatal predictors of mortality in very preterm infants cared for in the Australian and New Zealand Neonatal Network. Arch Dis Child Fetal Neonatal Ed 2007 Jan; 92(1):F34-40. https://doi.org/10.1136/adc.2006.094169
Tiskumara R., Fakharee S.H., Liu C.Q., et al. Neonatal infections in Asia. Arhc Dis Child Fetal Neonatal Ed 2009 Mar; 94(2): F144-8. https://doi.org/10.1136/adc.2008.139865
Miranda-del-Olmo H., Cardiel-Marmolejo L., Reynoso E., Oslas L., Acosta Gómez Y. Morbilidad y mortalidad en el recién nacido prematuro del Hospital General de México. Rev Med Hosp Gen Mex 2003 Ene-Mar; 66(1):22-28.
Haque K.N., Hayes A.M., Ahmed Z., Wilde R., Fong C.Y. Caesarean or vaginal Deli very for preterm verylow-birth weigth (< or = 1250 g) infant: experience from a district general hospital in UK. Arch Gyn Obstet 2008 Mar;277(3):207-12. https://doi.org/10.1007/s00404-007-0438-x
Muhuri P.K., Macdorman M.F., Menacker F. Method of delivery and neonatal mortality among very low birth weight infant in the United States. Matern Child Health J 2006 Jan; 10(1):47-53. https://doi.org/10.1007/s10995-005-0029-z
Slattery M.M., Geary M., Morrison J.J. Obstetric antecedents for preterm delivery. J Perinat Med 2008; 36(4):306-9. https://doi.org/10.1515/JPM.2008.045
Goldenberg R.L., Culhane J.F., Iams J.D., Romero R. Epidemiology and causes of preterm birth. Lancet 2008 Jan; 371(9606):75-84. https://doi.org/10.1016/S0140-6736(08)60074-4
Chandra S., Haines H., Michie C., Maheshwari A. Developmental Defects in Neutrophils from Preterm Infants. NeoReviews 2007; 8(9):368. https://doi.org/10.1542/neo.8-9-e368
Yost C.C., Cody M.J., Harris E.S., Thornton N.L., Mc Inturff AM, Martinez ML, et al. Impaired neutrophil extracellular trap (NET) formation: A novel innate immune deficiency of human neonates. Blood. 2009 Nov 26;114(23):4908-11
Stevens T.P., Harrington E.W., Blennow M., Soll R.F. Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or a t risk for respiratory distress syndrome. Cochrane Database Syst Rev 2007 Oct; (4):CD003063. https://doi.org/10.1002/14651858.CD003063.pub3
Ohls R.K. Transfusions in the Preterm Infant. NeoReviews 2007; 8(9):377. https://doi.org/10.1542/neo.8-9-e377
Chang TT. Transfusion therapy in critically ill children. Pediatr Neonatol 2008 Apr; 49(2):5-12. https://doi.org/10.1016/S1875-9572(08)60004-2
Roberts D., Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2007 Jan;3:CD004454. En: http://www.ncbi.nlm.nih.gov/pubmed/16856047. https://doi.org/10.1002/14651858.CD004454.pub2