Keywords
Queratinocitos
Dermatitis atópica
Paraqueratosis
Inflamación Giant cells
keratinocytes
Eczema
Atopic dermatitis
Parakeratoses
Inflammation
How to Cite
Abstract
Multinucleated keratinocytes are a specific histopathological finding in the diagnosis of some viral infectious skin diseases. For more than 30 years, other types of multinucleated keratinocytes have been identified in various conditions unrelated to cutaneous infectious processes such as eczema, multinuclear vulvar atypia, factitious dermatitis, psoriasis, connective tissue diseases and even alterations in the mucous membranes of the digestive tract (esophagus and intestine); however, very few clinical cases have been published so far and their pathophysiology is not entirely known. We present a clinical case with a finding of multinucleated keratinocytes in a middle-aged male patient with a final diagnosis of chronic eczema.
References
Kimura S, Hatano H. Multinucleate epidermal cells in non-neoplastic dermatoses. Br J Dermatol. 1978;99(5):485-9. https://doi.org/10.1111/j.1365-2133.1978.tb02014.x
Winters C, Machan M, Liu D, Fraga GR. Multinucleated giant cells in factitial dermatitis. J Cutan Pathol. 2013;40(2):205-8. https://doi.org/10.1111/cup.12080
Cohen PR, Paravar T, Lee RA. Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimica. Dermatol Pract Concept. 2014;4(4):21-7.
Sweeney SA, Sulit DJ, Adams EG, Shvartsman KR, Rapini RP. Grape Cells (Multinucleated Keratinocytes) in Noninfectious Dermatoses: Case Series and Review of the Literature. Am J Dermatopathol. 2015;37(12):e143-6. https://doi.org/10.1097/DAD.0000000000000330
Chen EH, Grote E, Mohler W, Vignery A. Cell-cell fusion. FEBS Lett. 2007;581(11):2181-93. https://doi.org/10.1016/j.febslet.2007.03.033
Tagami H, Uehara M. Multinucleated epidermal giant cells in inflammatory skin diseases. Arch Dermatol. 1981;117(1):23-5. https://doi.org/10.1001/archderm.1981.01650010029018
McLachlin CM, Mutter GL, Crum CP. Multinucleated atypia of the vulva. Report of a distinct entity not associated with human papillomavirus. Am J Surg Pathol. 1994;18(12):1233-9. https://doi.org/10.1097/00000478-199412000-00006
Goldberg LJ, Goldberg N, Abrahams I, Silvers DN, Szaniawski W, Halperin a J. Giant cell lichenoid dermatitis: a possible manifestation of sarcoidosis. J Cutan Pathol. 1994;21(1):47-51. https://doi.org/10.1111/j.1600-0560.1994.tb00690.x
Singh S., Odze R. Multinucleated Epithelial Giant Cell Changes in Esophagitis: A Clinicopathologic Study of 14 Cases. Am J Surg Pathol.199;22(1):93-9. https://doi.org/10.1097/00000478-199801000-00012
Kazakov D V, Michal M. Trichoepithelioma with giant and multinucleated neoplastic epithelial cells. Am J Dermatopathol. 2006;28(1):63-4. https://doi.org/10.1097/01.dad.0000158301.55910.0f
Lambie DLJ, Brown IS. Multinucleate epithelial change in colorectal hyperplastic polyps: a review of 27 cases. J Clin Pathol. 2008;61(5):611-4. https://doi.org/10.1136/jcp.2007.050849
Kambham N, Troxell M, Longacre T a. Multinucleated epithelial giant cells in colorectal polyps: a potential mimic of viropathic and/or dysplastic changes. Am J Surg Pathol. 2005;29(7):912-9.