Diagnostic consistency between tomosynthesis and biopsy in women with suspicious breast cancer lesions

Abstract

ammography is low. Nowadays, tomosynthesis is an additional tool available besides mammography, however there is limited national evidence regarding the diagnostic consistency between tomosynthesis and breast biopsy. Objectives: To estimate the consistency between tomosynthesis and breast biopsy in adult women with suspicious cancer lesions. Methodology: Retrospective, diagnostic concordance trial. Results: The principal group with biopsy-confirmed suspicious malignant breast lesions was between 50 and 60 years of age. The most frequent diagnoses with tomosynthesis were: nodules (27.5%) and microcalcifications (21.9%). With biopsy, 21.25% of the women had a diagnosis of infiltrating ductal carcinoma. BI-RADS 4 category was reported in 86% of the cases. The Kappa coefficient was of 0.406 (p<0.001) with tomosynthesis and biopsy in patients with suspicious lesions of the breast. The sensitivity and specificity was: 84% (95% CI 71.5% - 91.7%) and 63.6% (95% CI 54.3% - 72.0%) with positive and negative predictive values of 51.2% (95% CI 40.6% - 61.7%) and 89.7% (95% CI 81.0% - 94.7%) respectively. The mean radiation dose used was 7.9 mGy. Conclusions: There is moderate consistency between
tomosynthesis and the histopathological study of the breast. Tomosynthesis shows good sensitivity and acceptable specificity in the evaluation of suspicious breast lesions.