Keywords
Hemofilia
Radiosinoviortesis Systematic review
Hemophilia
Radiosynoviorthesis
How to Cite
Abstract
Introduction: the natural course of hemophilia presents with repeated hemarthrosis followed by the development of chronic synovitis. This results in the destruction of the cartilage (chondrolysis) and the development of osteoarthrosis of the joint. Some of the treatment options include education, prophylaxis, medical management and surgery. Radiosynoviorthesis (RSO) is part of the medical treatment envisaged to stabilize the synovial membrane by injecting an intra-joint radionuclide. Objective: to undertake a review of radiosynoviorthesis, its usefulness, indications and costs in the hemophilic patient. Methods: the keywords were used to search in MEDLINE and COCHRANE. 15 relevant articles were found and 11 secondary sources, all of which were used to prepare this review. Conclusions: radiosynoviorthesis is an effective procedure to control chronic synovitis. In countries where radionuclides are available, RSO is the first line of treatment for hemophilic arthropathy.
References
White GC, Rosendaal F, Aledort LM, Lusher JM. Definitions in Hemophilia. Blood Coagul Fibrinolysis. 2001;85:560. https://doi.org/10.1055/s-0037-1615621
Srivastava a, Brewer a K, Mauser-Bunschoten EP, Key NS, Kitchen S, Llinas a, et al. Guidelines for the management of hemophilia. Haemophilia [Internet]. 2013 Jan [cited 2014 Feb 19];19(1):e1-47. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22776238 https://doi.org/10.1111/j.1365-2516.2012.02909.x
Valentino LA, Hakobyan N, Rodriguez N, Hoots WK. Pathogenesis of haemophilic synovitis: experimental studies on blood-induced joint damage. Haemophilia. 2007;13(suppl.3.):10-3. https://doi.org/10.1111/j.1365-2516.2007.01534.x
Rodriguez-Merchan E. Haemophilic synovitis: basic concepts. Haemophilia. 2007;13(suppl. 3.):1-3. https://doi.org/10.1111/j.1365-2516.2007.01532.x
Rodríguez-Merchan E., Wiedel JD. General principles and indications of synoviorthesis (medical synovectomy) in hemophilia. Haemophilia. 2001;7(suppl. 2,):6-10. https://doi.org/10.1046/j.1365-2516.2001.00102.x
Rodríguez-Merchan E., Quintana M, De la Corte-Rodríguez H, Coya J. radioactive synoviorthesis for the treatment of haemophilic synovitis. Haemophilia. 2007;13(suppl. 3):32-7. https://doi.org/10.1111/j.1365-2516.2007.01538.x
Teyssler P, Taborska K, Kolostova K, Bobek V. Radiosynoviorthesis in hemophilic joints with yttrium-90 citrate and rhenium-186 sulfide and long term results. Hell J Nucl Med [Internet]. 2013;16(1):44-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23529393
Van der Wall EE, Scholte AJ, Bax JJ. Gated myocardial SPECT imaging; true additional value in AMI? Int J Cardiovasc Imaging [Internet]. 2010 Dec [cited 2013 Aug 25];26(8):893-6. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2991157&tool=pmcentre z&rendertype=abstract https://doi.org/10.1007/s10554-010-9650-z
Van der Zant FM, Jahangier ZN, Gommans GGM, Moolenburgh JD, Jacobs JWG. Radiation synovectomy of the upper extremity joints: does leakage from the joint to non-target organs impair its therapeutic effect? Appl Radiat Isot [Internet]. 2007 Jun [cited 2014 Feb 28];65(6):649-55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17350269 https://doi.org/10.1016/j.apradiso.2007.01.010
Pasta G, Mancuso ME, Perfetto OS, Solimeno LP. Radiosynoviorthesis in children with haemophilia. Hamostaseologie [Internet]. 2009 Oct;29 Suppl 1(6):S62-4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19763357 https://doi.org/10.1055/s-0037-1621502
Radiosynoviorthesis - indications, side effects. Hell J Nucl Med [Internet]. 2006;9(3):187. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17438175
Petersen CJ. Synoviorthesis with radioactive gold in haemophilia. Haemophilia. 2001;7(suppl.2.):31-3. https://doi.org/10.1046/j.1365-2516.2001.00106.x
Van der Zant FM, Boer RO, Moolenburgh JD, Jahangier ZN, Bijlsma JWJ, Jacobs JWG. Radiation synovectomy with (90)Yttrium, (186)Rhenium and (169)Erbium: a systematic literature review with meta-analyses. Clin Exp Rheumatol [Internet]. 2009;27(1):130-9. Available from: http:// www.ncbi.nlm.nih.gov/pubmed/19327243
Rodríguez-Merchan E., Jiménez-Yuste V, Villar A, Quintana M, López-Cabarcos C, Hernández-Navarro F. yttrium-90 synoviorthesis for chronic haemophilic synovitis: Madrid Experience. Haemophilia. 2001;7(suppl.2.):34-5. https://doi.org/10.1046/j.1365-2516.2001.00107.x
Kampen WU, Voth M, Pinkert J, Krause a. Therapeutic status of radiosynoviorthesis of the knee with yttrium [90Y] colloid in rheumatoid arthritis and related indications. Rheumatology (Oxford) [Internet]. 2007 Jan [cited 2014 Feb 28];46(1):16-24. Available from: http://www.ncbi. nlm.nih.gov/pubmed/17065191 https://doi.org/10.1093/rheumatology/kel352
Karavida N, Notopoulos a. Radiation Synovectomy: an effective alternative treatment for inflamed small joints. Hippokratia [Internet]. 2010 Jan;14(1):22-7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2843566&tool=pmcentrez&rendertype=abstract
Santos MF Dos, Furtado RNV, Konai MS, Castiglioni MLV, Marchetti RR, Natour J. Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial. Clinics (Sao Paulo) [Internet]. 2009 Jan [cited 2014 Feb 28];64(12):1187-93. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=27975 87&tool=pmcentrez&rendertype=abstract https://doi.org/10.1590/S1807-59322009001200008
Cho YJ, Kim KI, Chun YS, Rhyu KH, Kwon BK, Kim DY, et al. Radioisotope synoviorthesis with Holmium-166-chitosan complex in haemophilic arthropathy. Haemophilia [Internet]. 2010 Jul 1 [cited 2014 Feb 28];16(4):640-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20148979 https://doi.org/10.1111/j.1365-2516.2009.02192.x
Kraft O, Kaspárek R, Ullmann V, Melichar F, Kropácek M, Mirzajevova M. Radiosynoviorthesis of knees by means of 166Ho-holmium-boromacroaggregates. Cancer Biother Radiopharm [Internet]. 2007 Apr [cited 2014 Feb 28];22(2):296-302. Available from: http://www.ncbi.nlm. nih.gov/pubmed/17600479 https://doi.org/10.1089/cbr.2006.312
Rodríguez-Merchan E., Goddard NJ. The techinique of synoviorthesis. Haemophilia. 2001;7(suppl.2.):11-5. https://doi.org/10.1046/j.1365-2516.2001.00103.x
Manco-Johnson MJ, Nuss R, Lear J, Wiedel JD, Geraghty SJ, Hacker MR, et al. 32p radiosynoviorthesis in children with hemophilia. J Pediatr Hematol Oncol. 2002;24(7):534-9. https://doi.org/10.1097/00043426-200210000-00007
Fernández-Palazzi F, Caviglia H. on the safety of synoviorthesis in haemophilia. Haemophilia. 2001;7(suppl.2.):50-3. https://doi.org/10.1046/j.1365-2516.2001.00110.x
O'Duffy EK, Oliver FJ, Chatters SJ, Walker H, Lloyd DC, Edwards JC, et al. Chromosomal analysis of peripheral lymphocytes of patients before and after radiation synovectomy with samarium-153 particulate hydroxyapatite. Rheumatology (Oxford) [Internet]. 1999 Apr;38(4):316-20. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10378707 https://doi.org/10.1093/rheumatology/38.4.316
Infante-Rivard C, Rivard G-E, Derome F, Cusson a, Winikoff R, Chartrand R, et al. A retrospective cohort study of cancer incidence among patients treated with radiosynoviorthesis. Haemophilia [Internet]. 2012 Sep [cited 2014 Feb 28];18(5):805-9. Available from: http://www.ncbi. nlm.nih.gov/pubmed/22500891 https://doi.org/10.1111/j.1365-2516.2012.02802.x
Siegel ME, Siegel HJ, Luck J V. Radiosynovectomy's clinical applications and cost effectiveness: a review. Semin Nucl Med [Internet]. 1997 Oct;27(4):364-71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9364646 " https://doi.org/10.1016/S0001-2998(97)80009-8