Abstract
Purpose: To determine prognostic factors, macular morphology and nerve fiber ganglion layer changes after pars plana vitrectomy, at Fundación Oftalmológica Nacional. Methodology: Before and after pars plana vitrectomy (3 and 6 months) longitudinal study involving patients with epiretinal membrane, macular hole, macular vitreous traction syndrome and noninflammatory vitreous opacities. Clinical and optic coherence tomography monitoring were done. Results: Sixty patients (65.0% women), with average age of 65.45+9.49 years, and mean disease duration of 23+29.79months. The indications for pars plana vitrectomy (n=60 eyes) were macular hole (38.3%) and epiretinal membrane (36.7%). Significant difference was observed in the thickness of ganglion cell layer +inner plexiform layer complex at baseline and third month (p=0.039), correlation between complex at third and sixth months (r=0.704,p<0.001) and complex at third month with central foveal thickness at third and sixth months (r=–0.594,p<0.001 and r=–0.595,p=0.001). Patients older than 65 years have less ganglion cell layer thickness at six months (r=-0.528,p=0.007). Ganglion cellular fiber layer average thickness and the presence of ellipsoid layer were baseline predictors of good visual acuity after pars plana vitrectomy (r2=0.414,p=0.018, and r2=0.414,p=0.010). Conclusion: Ganglion cellular nerve fiber layer thickness and the presence of the ellipsoid zone at baseline are highly predictive of good visual acuity at the third postoperative month of pars plana vitrectomy and there is an inverse correlation between complex with central foveal thickness at third and sixth months after pars plana vitrectomy.
References
Ryan S, Wilkinson C. Capítulo 125: Principios y técnicas de la cirugía vítreorretiniana. In: Retina. Cuarta edición. New York: Elsevier; p. 1917-31.
Kinoshita T, Kovacs K, Wagley S, Arroyo J. Morphologic differences in epiretinal membranes on ocular coherence tomography as a predictive factor for surgical outcome. Retina. 2011;31:1692-1698. https://doi.org/10.1097/IAE.0b013e31820f49d0
Academia Americana de Oftalmología. Capítulo 15: Cirugía vítreorretiniana. In: Curso de ciencias básicas y clínicas: Retina y Vítreo. Madrid, España.: Elsevier; 2009. p. 369.
Kim Jiramongkolchai, Maziar Lalezary, Stephen J Kim. Influence of previous vitrectomy on incidence of macular oedema after cataract surgery in diabetic eyes. Br J Ophthalmol. 2011;95:524-9. https://doi.org/10.1136/bjo.2010.182477
S. Kim SJ, Martin DF, Hubbard GB 3rd, Srivastava SK, Yan J, Bergstrom CS, Aaberg TM Sr. Incidence of postvitrectomy macular edema using optical coherence tomography. Ophthalmology. 2009;116(8):1531-7. https://doi.org/10.1016/j.ophtha.2009.02.008
Staudt S, Miller DW, Unnebrink K, Holz FG. Incidence and extent of postoperative macular edema following vitreoretinal surgery with and without combined cataract operation. Ophthalmologe. 2003;100(3):702-7. https://doi.org/10.1007/s00347-003-0821-3
Loewenstein A, Zur D. Postsurgical Cystoid Macular Edema. Dev Ophthalmol. 2010;47:148-159. https://doi.org/10.1159/000320078
Scarpa G. Bilateral cystoid macular edema after cataract surgery resolved by vitrectomy. Eur J Ophthalmol. 2011;21(5):677-9. https://doi.org/10.5301/EJO.2011.6506
Noma H, Mimura T, Shimada K. Changes of macular sensitivity and morphology after pars plana vitrectomy for macular edema with central retinal vein occlusion: a case series. BMC Ophthalmology. 2013;13(2). https://doi.org/10.1186/1471-2415-13-2
Hassenstein A, Scholz F, Richard G. OCT in epiretinal gliosis. Ophthalmologe. 2005;102(2):127-132. https://doi.org/10.1007/s00347-004-1055-8
Noma H, Funatsu H, Mimura T, Shimada K. Visual Acuity and Foveal Thickness after Vitrectomy for Macular Edema. Ophthalmologica. 2010;224:367- 373. https://doi.org/10.1159/000313819
Zhou J, Liu W, Li Q, Li X, Hao J, Wang XL. A comparative study of macular thickness and function before and after idiopathic macular epiretinal membrane surgery. Zhonghua Yan Ke Za Zhi. 2012;48(2):119-23.
Kim J, Min Rhee K, Joon Woo S, Suk Yu Y,Chung H. Long-term Temporal Changes of Macular Thickness and Visual Outcome after Vitrectomy for Idiopathic Epiretinal Membrane. Am J Ophthalmol. 2010;150:701-709. https://doi.org/10.1016/j.ajo.2010.05.037
Massin P, Allouch C, Haouchine B, et al. Optical coherence tomography of idiopathic macular epiretinal membranes before and after surgery. Am J Ophthalmol. 2000;130(6):732-739. https://doi.org/10.1016/S0002-9394(00)00574-2
Ishida M, Takeuchi S, Nakamura M, Morimoto K, Okisaka S. The surgical outcome of vitrectomy for idiopathic epiretinal membranes and foveal thickness before and after surgery. Nippon Ganka Gakkai Zasshi. 2004;108(1):18 -22.
Yamashita T, Uemura A, Kita H, Sakamoto T. Analysis of the retinal nerve fiber layer after indocyanine green-assisted vitrectomy for idiopathic macular holes. Ophthalmology. 2006;113(2):280-284. https://doi.org/10.1016/j.ophtha.2005.10.046
Aso H, Iijima H, Imai M, Gotoh T. Temporal changes in retinal thickness after removal of the epiretinal membrane. Acta Ophthalmologica. 2009;87:419-423. https://doi.org/10.1111/j.1755-3768.2008.01264.x
Ferreira J, Machado I, Lopez T, Pistarini F, Negretto A, Nakashima Y, et al. Study on macular morphology after removal of the idiopathic epiretinal membrane using the optical coherence tomography (OCT): a pilot study. Arq Bras Oftalmol. 2007;70(6):935-8. https://doi.org/10.1590/S0004-27492007000600009
Shiono A, Kogo J, Klose G, Takeda H, Ueno H, Tokuda N, Inoue J, Matsuzawa A, Kayama N, Ueno S, Takagi H. Photoreceptor outer segment length: a prognostic factor for idiopathic epiretinal membrane surgery. Ophthalmology. 2013;120:788-794. https://doi.org/10.1016/j.ophtha.2012.09.044
Kook Young Kim, Seung-Young Yu, Moo Sang Kim, Eung Suk Kim, Hyung Woo Kwak. Changes of paravoveal retinal nerve fiber layer thickness analyzed by spectral - domain optical coherence tomography after pars plana vitrectomy. Retina. 2013;33:776-784. https://doi.org/10.1097/IAE.0b013e31826a68ab
Brazitikos P, Katsimpris J, Tsironi E, Androudi S. Retinal nerve fiber layer thickness evaluation after trypan blue-assisted macular surgery. Retina. 2010;30:640-647. https://doi.org/10.1097/IAE.0b013e3181c085ab
República de Colombia - Ministerio de Salud. Resolución No 008430 de 1993 (4 de octubre de 1993). 1993.